Studies on Oxytocin – A non-exhaustive list of recent studies that may be of use to Brain Tumour Survivors

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Time has been ticking by, and time keeps increasing my daughter’s weight. We don’t feel we have time to wait for ‘someone’ ‘somewhere’ to conduct a trial on Oxytocin therapy in Brain Tumour Survivors – if ever anyone does – so we are trying it now. It may not work, if it doesn’t we will return to the drawing board, happy at least that we know.

Since I published my Plea: A Plea to scientists around the world; ‘Study Oxytocin for Brain Tumour survivors, Please!‘ two days ago I’ve been contacted by brain tumour survivors and their parents from  all over the world who are also interested in the findings of current studies on Oxytocin. Many also want to discuss possibility of trying it themselves with their doctors.  Like us, they are desperate for help, desperate for any chance to improve their own quality of life or the lives of their loved ones. I decided to put together this short list of studies, it is by no means exhaustive but could be used as a tool to give interested doctors a glimpse at where therapeutic Oxytocin is sitting in research right now. This article can be printed and taken to appointments, or even better forwarded to interested doctors who need then only click on the hyperlinks of the listed articles to be taken straight to the abstracts or full articles.

Disclaimer: Although my own daughter has started taking Oxytocin I do not/cannot advocate its use in anyone else as I am not a doctor nor a scientist. I am writing this post as a mother (who happens to be a nurse) who is searching for a way to improve her own daughter’s quality of life. I do, however want to help inform others and thus want to share my research findings, I welcome the addition of further references and links to studies in the comments section. 

Reader Friendly Overviews of Oxytocin

This is a nice, consumer-friendly overview of Mood Enhancement and Oxytocin Therapy by Femme Clinique

This is the first article posted in the Craniopharyngioma Facebook group by Brooke who was the first to spot the link between Oxytocin and appetite. It is a very general, reader friendly place to start for those interested in learning more about Oxytocin: 10 reasons why Oxytocin is the most amazing molecule in the world

Scientific Studies on Oxytocin

Oxytocin; Love and Trust Hormone

IJzendoom e& Bakermans Kranenburg; A sniff of trust: Meta-analysis of the effects of intranasal oxytocin administration on face recognition, trust to in-group, and trust to out-group Psedoneuroendocrinology, March 2012

Oxytocin for improved Social Interaction and Communication (Autism Studies)

 Guastella et al, Intranasal Oxytocin Improves Emotion Recognition for Youth with Autism Spectrum Disorders, Biological Psychiatry 2009

Gordon et al, Oxytocin enhances Brain Function in children with Autism, PNAS 2013 This study includes children as young as 7 in their sample and also discusses doses for each age group in the study.

Oxytocin for Reducing Food Focus

King’s College summary: Oxytocin could provide new treatment for Anorexia 

Kim, Y-R. et al. ‘Intranasal oxytocin attenuates attentional bias for eating and fat shape stimuli in patients with anorexia nervosa’ published in Psychoneuroendocrinology, June 2014

Kim, Y-R. et al. ‘The impact of intranasal oxytocin on attention to social emotional stimuli in patients with anorexia nervosa: a double blind within subject cross-over experiment’ published in PLOS ONE on 6th March 2014

Oxytocin for Appetite Control and Weight Loss via Metabolic Changes

Two studies on mice with diet induced obesity demonstrated reduced hyperphagic tendencies and weight loss after Oxytocin administration:

Deblon et al, Mechanisms of the Anti-Obesity Effects of Oxytocin in Diet-Induced Obese Rats published 27 September 2011, PLOS ONE

Here is an article on Science Daily, called: ‘Hormone, Oxytocin, shows potential as weight loss treatment’ based on the below study by Maejima, 2011. The authors claim that Oxytocin has potential to treat obesity and hyperphagia, here is the full study:

Maejima Y, et al. Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging, 3(12), 1169-1177, 2011

The first human trial was in 2013, obese human subjects were administered Oxytocin and  lost weight which the authors claim seemed occur in a similar fashion to the metabolic changes associated with surgical lap-banding:

Zhang, Wu and Chen et al. Treatment of Obesity and Diabetes using Oxytocin or Analogs in patients and mouse models published in   PLOS ONE May 20th, 2013

 

I hope you all find this helpful and I’d love to know how you get on, what your doctors think, and how you feel if you start using Oxytocin. As some of you know, I have found a doctor who supports the concept of  oxytocin therapy in our daughter in light of her recent  Craniopharyngioma and subsequent hormonal deficiencies. I will be blogging our progress as we start her oxytocin replacement therapy this week.

Thanks for reading, there is more on our Brain Tumour Journey here and I usually update my Facebook page daily. 

For more on my recent thoughts on Oxytocin have a look at:

WOW! Is this a potential cure for my daughter’s obesity and extreme hunger?

My daughter NEEDS oxytocin after her craniopharyngioma brain tumour. But why isn’t she getting it?

 

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